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Increased Carotid Artery Intima-Media Thickness in Subjects With Primary Hypoalphalipoproteinemia by Damiano Baldassarre; Mauro Amato; Linda Pustina; Elena Tremoli; Cesare R. Sirtori; Laura Calabresi; Guido Franceschini is a Medicine article available to read on EtoBox.

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The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study, we evaluated pre-intrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age, and plasma cholesterol. The average and maximal intima-media thicknesses (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than in control subjects (0.94±0.06 versus 0.69±0.04 mm, __P__ =0.004, and 1.86±0.16 versus 1.35±0.10 mm, __P__ =0.025, respectively). The IMT values in HyperALP subjects (Avg-IMT, 0.71±0.04 and Max-IMT, 1.38±0.14 mm) were the same as in controls. In a large cohort of hyperlipidemic subjects (n=559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (<42 mg/dL) than in all the others. The measurement of carotid IMT in cases with HypoALP and HyperALP, and in a large series

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Author

Damiano Baldassarre; Mauro Amato; Linda Pustina; Elena Tremoli; Cesare R. Sirtori; Laura Calabresi; Guido Franceschini

Publisher

Lippincott Williams and Wilkins; Ovid Technologies Wolters Kluwer -American Heart Association; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1079-5642)

Published

2002

Language

EN

Field

Medicine (Health Sciences)