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Combination of Alpha-fetoprotein and Neutrophil-to-lymphocyte Ratio to Predict Treatment Response and Survival Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors by Hong-Fei Zhu; Jin-Kai Feng; Yan-Jun Xiang; Kang Wang; Li-Ping Zhou; Zong-Han Liu; Yu-Qiang Cheng; Jie Shi; Wei-Xing Guo; Shu-Qun Cheng is a Medicine article available to read on EtoBox.

What is Combination of Alpha-fetoprotein and Neutrophil-to-lymphocyte Ratio to Predict Treatment Response and Survival Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors about?

## Background Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of hepatocellular carcinoma (HCC). However, long-term survival outcomes and treatment response of HCC patients undergoing immunotherapy is unpredictable. The study aimed to evaluate the role of alpha-fetoprotein (AFP) combined with neutrophil-to-lymphocyte ratio (NLR) to predict the prognosis and treatment response of HCC patients receiving ICIs. ## Methods Patients with unresectable HCC who received ICI treatment were included. The HCC immunotherapy score was developed from a retrospective cohort at the Eastern Hepatobiliary Surgery Hospital to form the training cohort. The clinical variables independently associated with overall survival (OS) were identified using univariate and multivariate Cox regression analysis. Based on multivariate analysis of OS, a predictive score based on AFP and NLR was constructed, and patients were stratified into three risk groups according to this score. The clinical utility of this score to predict progression-free survival (PFS) and differentiate objective response rate (ORR) and disease control rate (DCR) was also performed. This score was validated in an independ

Who reads Combination of Alpha-fetoprotein and Neutrophil-to-lymphocyte Ratio to Predict Treatment Response and Survival Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors?

Author

Hong-Fei Zhu; Jin-Kai Feng; Yan-Jun Xiang; Kang Wang; Li-Ping Zhou; Zong-Han Liu; Yu-Qiang Cheng; Jie Shi; Wei-Xing Guo; Shu-Qun Cheng

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)