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Macrophage Efferocytosis in Health and Disease by Shokufeh Razi; Javad Yaghmoorian Khojini; Fateme Kargarijam; Susan Panahi; Zahra Tahershamsi; Amir Tajbakhsh; Seyed Mohammad Gheibihayat is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Macrophage Efferocytosis in Health and Disease about?

Creating cellular homeostasis within a defined tissue typically relates to the processes of apoptosis and efferocytosis. A great example here is cell debris that must be removed to prevent unwanted inflammatory responses and then reduce autoimmunity. In view of that, defective efferocytosis is often assumed to be responsible for the improper clearance of apoptotic cells (ACs). This predicament triggers off inflammation and even results in disease development. Any disruption of phagocytic receptors, molecules as bridging groups, or signaling routes can also inhibit macrophage efferocytosis and lead to the impaired clearance of the apoptotic body. In this line, macrophages as professional phagocytic cells take the lead in the efferocytosis process. As well, insufficiency in macrophage efferocytosis facilitates the spread of a wide variety of diseases, including neurodegenerative diseases, kidney problems, types of cancer, asthma, and the like. Establishing the functions of macrophages in this respect can be thus useful in the treatment of many diseases. Against this background, this review aimed to recapitulate the knowledge about the mechanisms related to macrophage polarization und

Who reads Macrophage Efferocytosis in Health and Disease?

Author

Shokufeh Razi; Javad Yaghmoorian Khojini; Fateme Kargarijam; Susan Panahi; Zahra Tahershamsi; Amir Tajbakhsh; Seyed Mohammad Gheibihayat

Publisher

Wiley

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)