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Estimated cut-off values for pemphigus severity classification according to pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and anti-desmoglein 1 autoantibodies by Mohebi, Farnam; Tavakolpour, Soheil; Teimourpour, Amir; Toosi, Roja; Mahmoudi, Hamidreza; Balighi, Kamran; Ghandi, Narges; Ghiasi, Maryam; Nourmohammadpour, Pedram; Lajevardi, Vahideh; Abedini, Robabeh; Azizpour, Armaghan; Nasimi, Maryam; Daneshpazhooh, Maryam is a Medicine article available to read on EtoBox.

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## Abstract ## Background Pemphigus is a potentially fatal disease if left untreated. Valid scoring systems and defined cut-off values for classification of patients would help with better management through specified pharmaceutical and non-pharmaceutical treatments. ## Methods In this study, pemphigus patients who were receiving immunosuppressive treatments and had recent disease relapse were recruited for examination of pemphigus disease area index(PDAI), autoimmune bullous skin disorder intensity score (ABSIS), physician global assessment (PGA), autoimmune bullous disease quality of life (ABQoL), anti-desmoglein 1 (anti-Dsg1), and anti-Dsg3 autoantibody titers from December-2017 to February-2018. Cut-off values were estimated using model-based clustering classification and the 25th and 75th percentiles approach, performed separately for the exclusive cutaneous, exclusive mucosal, and mucocutaneous groups. ## Results In the 109 included patients, the 25th and 75th percentiles cut-offs were 6.2 and 27 for PDAI score, and 4 and 29.5 for ABSIS score. The model-based analysis resulted in two groups (cut-point:15) for PDAI score, and three groups (cut-points:6.4 and 31.5) for ABSIS sc

Who reads Estimated cut-off values for pemphigus severity classification according to pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and anti-desmoglein 1 autoantibodies?

Author

Mohebi, Farnam; Tavakolpour, Soheil; Teimourpour, Amir; Toosi, Roja; Mahmoudi, Hamidreza; Balighi, Kamran; Ghandi, Narges; Ghiasi, Maryam; Nourmohammadpour, Pedram; Lajevardi, Vahideh; Abedini, Robabeh; Azizpour, Armaghan; Nasimi, Maryam; Daneshpazhooh, Maryam

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Progettinrete Srl (ISSN 1471-5945)

Published

2020

Language

EN

Field

Medicine (Health Sciences)