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Increased Fetal Cell Microchimerism in High Grade Breast Carcinomas Occurring During Pregnancy by Gil Dubernard; Michel Oster; Fabrice Chareyre; Martine Antoine; Roman Rouzier; Serge Uzan; Selim Aractingi; Kiarash Khosrotehrani is a Medicine article available to read on EtoBox.

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## Abstract Pregnancy results in the transfer of stem cells from the fetus to the maternal circulation. These cells are able to migrate and differentiate within various damaged maternal tissues. We recently showed the presence of fetal‐derived cells in human breast carcinomas during pregnancy. In this study, we aimed to reproduce these results in a murine model of “pregnancy‐associated” breast carcinoma. We bred virgin MMTV‐H‐Ras transgenic female mice with male mice transgenic for luciferase under the control of the VEGFR2 promoter. Tumors that developed during or following gestation were analyzed and their nuclear grade classified. Fetal cells were detected by Y chromosome Fluorescence __in situ__ hybridization FISH in 9/9 of breast carcinomas but only in 2 liver controls from the same animals. The number of fetal cells was 20 and 4.9 per million maternal cells in these tissues, respectively (__p__ < 0.05). High grade tumors had significantly more fetal cells (__p__ < 0.05). __In vivo__ imaging of the luciferase signal under control of the VEGFR2 promoter as well as von Willebrand staining did not reveal an endothelial phenotype of fetal cells. Sixty two percent of the fetal cell

Who reads Increased Fetal Cell Microchimerism in High Grade Breast Carcinomas Occurring During Pregnancy?

Author

Gil Dubernard; Michel Oster; Fabrice Chareyre; Martine Antoine; Roman Rouzier; Serge Uzan; Selim Aractingi; Kiarash Khosrotehrani

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2008

Language

EN

Field

Medicine (Health Sciences)