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The document discusses the interaction between αT-catenin and plakophilin-2, which are proteins found in cardiac muscle cell junctions. It was found that αT-catenin specifically interacts with plakophilin-2 and other plakophilins. This interaction may strengthen cell-cell adhesion in the heart by providing an additional link between cadherin-catenin complexes and intermediate filaments. Mutations affecting this interaction could contribute to heart muscle dysfunction.
- Author
- Geethu San
- Language
- EN