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Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunity by Marion Espeli; Heather A Niederer; James A Traherne; John Trowsdale; Kenneth GC Smith is a Immunology and Microbiology article available to read on EtoBox.

What is Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunity about?

Recent work has emphasised the marked genetic variability that exists in the Fc receptor locus. This variation can contribute to the risk of autoimmune disease in both mice and humans, but can also have a profound impact on defence against infection. Using FcgRIIB and FcgRIIIB as examples, we demonstrate that variations associated with increased susceptibility to autoimmunity may be maintained in populations for their beneficial effect against infection. We examine the KIR locus from the same perspective and highlight similarities between the two loci. Intense selection pressure by pathogens presumably accounts for the marked variability within both regions and leads to susceptibility to autoimmunity for some alleles.

Who reads Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunity?

Author

Marion Espeli; Heather A Niederer; James A Traherne; John Trowsdale; Kenneth GC Smith

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0952-7915)

Published

2010

Language

EN

Field

Immunology and Microbiology (Life Sciences)