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Macrophage Metabolic Reprogramming Via HIF-1 Glycolysis Drives Osteoblast Fe by hang.zhong is a document available to read on EtoBox.

This study investigates the role of macrophage metabolic reprogramming via HIF-1α-glycolysis in driving osteoblast ferroptosis and bone loss in postmenopausal osteoporosis (PMOP). The researchers found that pharmacological disruption of this pathway using valproic acid (VPA) can protect osteoblasts from ferroptosis and improve bone mass in ovariectomized rats. The findings suggest that targeting the HIF-1α-glycolysis axis may offer a novel therapeutic strategy for managing PMOP-related bone loss.

Author

hang.zhong

Language

EN