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Circular RNA FOXO3 Suppresses Bladder Cancer Progression and Metastasis by Regulating MiR-9-5p/TGFBR2 by Yongxiang Li; Liang Qiao; Yuanwei Zang; Wenjun Ni; Zhonghua Xu is a Medicine article available to read on EtoBox.

What is Circular RNA FOXO3 Suppresses Bladder Cancer Progression and Metastasis by Regulating MiR-9-5p/TGFBR2 about?

## Background Increasing evidence indicates that the dysregulation of circular RNAs (circRNAs) plays important roles in tumor progressions. ## Methods In this study, we first analyzed circ-FOXO3 level in bladder cancers (BCs), and then BC cell lines were transfected with circ-FOXO3 expression vector, and cell proliferation, migration, and invasion abilities were analyzed. We also used bioinformatics tools to predict potential-binding miRNAs for circ-FOXO3, and luciferase reporter assay was used for the verification of binding miRNAs. For the further study, we analyzed potential downstream-binding mRNA for miRNA, and cell proliferation, migration and invasion abilities of it were also studied. ## Results We found that circ-FOXO3 was significantly down-regulated in bladder cancer (BC) tissues compared to normal bladder tissues. We also found that circ-FOXO3 overexpression inhibited cell proliferation, migration and invasion in BC cell lines. Moreover, we demonstrated that TGFBR2 was regulated by circ-FOXO3 through sponging miR-9-5p, the knockdown of TGFBR2 or the overexpression of miR-9-5p all related to the increased BC cell proliferation, migration, and invasion. ## Discussion In s

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Author

Yongxiang Li; Liang Qiao; Yuanwei Zang; Wenjun Ni; Zhonghua Xu

Publisher

Informa UK Limited

Published

2020

Language

EN

Field

Medicine (Health Sciences)