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Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas by S Tedoldi; JC Paterson; J Cordell; S-Y Tan; M Jones; S Manek; AP Dei Tos; H Roberton; N Masir; Y Natkunam; SA Pileri; F Facchetti; M-L Hansmann; DY Mason; T Marafioti is a Medicine article available to read on EtoBox.
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## Abstract Jaw1, also known as lymphoid‐restricted membrane protein (LRMP), is an endoplasmic reticulum‐associated protein. High levels of __Jaw1/LRMP__ mRNA have been found in germinal centre B‐cells and in diffuse large B‐cell lymphomas of ‘germinal centre’ subtype. This paper documents Jaw1/LRMP expression at the protein level in human tissues by immunohistochemical and western blotting analysis using an antibody reactive with paraffin‐embedded tissues. Jaw1/LRMP was highly expressed in germinal centre B‐cells (in keeping with gene expression data), in ‘monocytoid B‐cells’, and in splenic marginal zone B‐cells. It was absent, or present at only low levels, in mature T‐cells, although cortical thymocytes were weakly positive. Among lymphoid neoplasms, Jaw1/LRMP was found in germinal centre‐derived lymphomas (follicle centre lymphoma, Burkitt's lymphoma, lymphocyte‐predominant Hodgkin's disease) but not in T‐cell neoplasms (with the exception of a single T lymphoblastic lymphoma). Classical Hodgkin's disease and myeloma lacked Jaw1/LRMP but many cases of chronic lymphocytic leukaemia (but not mantle zone lymphoma) were Jaw1/LRMP‐positive. Approximately half of the marginal zone l
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- Author
- S Tedoldi; JC Paterson; J Cordell; S-Y Tan; M Jones; S Manek; AP Dei Tos; H Roberton; N Masir; Y Natkunam; SA Pileri; F Facchetti; M-L Hansmann; DY Mason; T Marafioti
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)