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Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer by D. Pettersson; B. Cedermark; T. Holm; C. Radu; L. Påhlman; B. Glimelius; A. Martling is a Medicine article available to read on EtoBox.

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## Abstract ## Background To address issues regarding the fractionation of radiotherapy (RT) and timing of surgery for rectal cancer, a multicentre trial has randomized patients to preoperative short-course RT with two different intervals to surgery, or long-course RT with delayed surgery. The present interim analysis assessed feasibility, compliance and complications after RT and surgery. ## Methods Some 303 patients were randomized to either short-course RT (5 × 5 Gy) and surgery within 1 week (group 1), short-course RT and surgery after 4–8 weeks (group 2) or long-course RT (25 × 2 Gy) and surgery after 4–8 weeks (group 3). ## Results Demographic data were similar between groups and there were few protocol violations (5·0–6 per cent). Eight patients (2·6 per cent) developed radiation-induced acute toxicity. There were no significant differences in postoperative complications between groups (46·6, 40·0 and 32 per cent in groups 1, 2 and 3 respectively; P = 0·164). Patients receiving short-course RT with surgery 11–17 days after the start of RT had the highest complication rate (24 of 37). ## Conclusion Compliance was acceptable and severe acute toxicity was low, irrespective of f

Who reads Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer?

Author

D. Pettersson; B. Cedermark; T. Holm; C. Radu; L. Påhlman; B. Glimelius; A. Martling

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Oxford University Press (OUP) (ISSN 0007-1323)

Published

2010

Language

EN

Field

Medicine (Health Sciences)