About this Medicine article
Treatment of canine Alopecia X with trilostane by ROSARIO CERUNDOLO; DAVID H. LLOYD; ANGELO PERSECHINO; HELEN EVANS; ANDRIA CAUVIN is a Medicine article available to read on EtoBox.
**Abstract** Sixteen Pomeranians and eight miniature poodles presenting with clinical signs of alopecia X, elevated blood concentrations of 17‐hydroxyprogesterone post stimulation with adrenocorticotropic hormone and increased urinary cortisol/creatinine ratios were treated with trilostane, a competitive inhibitor of 3β‐hydroxysteroid dehydrogenase. Trilostane was given once or twice daily at a mean dose of 10.85 mg kg^−1^ day^−1^. Adrenal function was evaluated with a follow‐up of 28 months in the Pomeranians and 33 months in the miniature poodles. Treatment with trilostane led to complete hair re‐growth in 85% of the Pomeranians and in all of the miniature poodles within 4 to 8 weeks. No adverse events attributed to treatment with trilostane were recognized. The hair re‐growth might have been the result of a down‐regulation of adrenal steroids and/or of the noncompetitive inhibition of the oestrogen receptors at the hair follicle level.
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- Author
- ROSARIO CERUNDOLO; DAVID H. LLOYD; ANGELO PERSECHINO; HELEN EVANS; ANDRIA CAUVIN
- Publisher
- Wiley
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)