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Endothelin-1- and Endothelin-Receptors in Lung Biopsies of Patients with Pulmonary Hypertension due to Congenital Heart Disease by Jens Lutz; Matthias Gorenflo; Matthias Habighorst; Martin Vogel; Peter E. Lange; Berthold Hocher is a Medicine article available to read on EtoBox.
What is Endothelin-1- and Endothelin-Receptors in Lung Biopsies of Patients with Pulmonary Hypertension due to Congenital Heart Disease about?
## Abstract Endothelin-1 (ET-1), with its vasoconstrictive and proliferation-stimulating effects, could play a role in the pathogenesis of primary pulmonary hypertension. We investigated the relationship between the ET-1 like immunoreactivity and the ET-receptor density, the grade of the pulmonary vasculopathy, and properties of the pulmonary circulation in patients with pulmonary hypertension due to congenital heart disease. Twenty-six patients with a median age of 1 year and 1 month (6 weeks–17 years–9 months) were assigned to group I (n = 15) with a pulmonary to systemic flow ratio (Qp/Qs) ≥ 1.5 and a pulmonary to systemic resistance ratio (Rp/Rs) ≤ 0.3 (“high flow–low resistance group”) and to group II (n = 11) with a Qp/Qs 0.3 (“low flow–high resistance group”). Patients belonging to group II showed a higher ET~A~-receptor density in lung arteries (p < 0.05) and parenchyma (p < 0.01) than patients in group I. Patients with the highest ET-1 like immunoreactivity in lung artery walls also showed a trend towards a higher ET~A~-receptor density. The ET~B~-receptor expression was low and not related to any of the above factors. Our results suggest that the paracrine lung ET-1 sys
Who reads Endothelin-1- and Endothelin-Receptors in Lung Biopsies of Patients with Pulmonary Hypertension due to Congenital Heart Disease?
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- Author
- Jens Lutz; Matthias Gorenflo; Matthias Habighorst; Martin Vogel; Peter E. Lange; Berthold Hocher
- Publisher
- Walter de Gruyter GmbH & Co. KG; Walter de Gruyter GmbH (ISSN 1434-6621)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)