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JC Article by hepatologyacademics is a document available to read on EtoBox.

The study investigates the role of AF6 knockout in enhancing bile acid production, which promotes CXCL14-mediated antitumor immunity in hepatocellular carcinoma (HCC). AF6 deficiency leads to increased primary bile acid levels and altered gut microbiota, resulting in elevated butyrate production that reshapes the tumor microenvironment and enhances immune response. This research highlights a novel mechanism linking bile acid metabolism, gut microbiota, and immune regulation, suggesting potential therapeutic

Author

hepatologyacademics

Language

EN