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Radiochemical Purification of No-carrier-added Scandium-47 for Radioimmunotherapy by K.L. Kolsky; V. Joshi; L.F. Mausner; S.C. Srivastava is a Physics and Astronomy article available to read on EtoBox.

What is Radiochemical Purification of No-carrier-added Scandium-47 for Radioimmunotherapy about?

A procedure, adaptable to large-scale remote operation, was developed to purify no-carrier-added (NCA) 47Sc from irradiated Ti targets. Methods based on extraction chromatography and cation-exchange chromatography were compared. Results of this comparison led to the development of an optimized procedure based on cation-exchange with Dowex AG 50W-X4 and 47Sc elution with HCl/HF. This method gave 90-97% overall 47Sc recovery, with a Ti separation factor greater than 2.4 x 10(-5), and specific activities > or = 0.9 GBq microgram-1. Use of the 47Sc product, for labeling monoclonal antibodies, resulted in consistent labeling yields of > or = 90%.

Who reads Radiochemical Purification of No-carrier-added Scandium-47 for Radioimmunotherapy?

Author

K.L. Kolsky; V. Joshi; L.F. Mausner; S.C. Srivastava

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0969-8043)

Published

1998

Language

EN

Field

Physics and Astronomy (Physical Sciences)