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Effects of fermented feed on growth performance, immune response, and antioxidant capacity in laying hen chicks and the underlying molecular mechanism involving nuclear factor-κB by Fenghua Zhu; Beibei Zhang; Jin Li; Lianqin Zhu is a Agricultural and Biological Sciences article available to read on EtoBox.

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This study investigated the effects of fermented-feed diets on growth performance, immune status, and antioxidant responses in laying hen chicks and the underlying molecular mechanism, specifically, the role of the nuclear factor-κB (**NF-κB**) signaling pathway. A total of 80 healthy 14-day-old laying hen chicks were randomly divided into 4 treatments: basal diet (**CON**); basal diet supplemented with 7.5% fermented feed (**FD**); FD diet plus the NF-κB inhibitor BAY 11-7082 (**FD + BAY**); and FD diet plus the NF-κB inhibitor JSH-23 (**FD + JSH**). The NF-κB inhibitors were administered by intraperitoneal injection. The experiment lasted 21 D. Fermented feed supplementation significantly increased the body weight and average body weight gain of laying hen chicks but significantly decreased the feed conversion ratio. Additionally, fermented feed supplementation significantly increased mitogen-activated T-cell and B-cell proliferation in the peripheral blood, as well as elevated the serum concentrations of interleukin (**IL**)-1, IL-2, IL-4, IL-6, and tumor necrosis factor (**TNF-α**); however, NF-κB inhibition significantly reduced T-cell proliferation and serum IL-1, IL-6, and T

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Author

Fenghua Zhu; Beibei Zhang; Jin Li; Lianqin Zhu

Publisher

Poultry Science Association; Oxford University Press; Elsevier BV; Oxford University Press (OUP) (ISSN 0032-5791)

Published

2020

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)