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Detection of Galanin Receptors in the Spinal Cord in Experimental Autoimmune Encephalomyelitis by Danica Michalickova; Ivana Kramarikova; Hatice Kubra Ozturk; Tomas Kucera; Tomas Vacik; Tomas Hrncir; Nikolina Kutinova Canova; Martin Sima; Ondrej Slanar is a scholarly article available to read on EtoBox.

What is Detection of Galanin Receptors in the Spinal Cord in Experimental Autoimmune Encephalomyelitis about?

This study investigated the expression of galanin receptors (GalR1, GalR2, GalR3) in the spinal cord in a murine model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) by qPCR analysis and determined GalR1 cellular localization (oligodendrocytes, microglia, astrocytes, ependymal cells, and endothelial cells in the capillaries) by immunohistochemistry. qPCR analysis revealed that GalR1 mRNA levels is decreased in the EAE mice compared to controls, whereas mRNA level of GalR2 and GalR3 were not significantly different from the controls. Immunochemical detection of the GalR1 revealed its expression in the ependymal and endothelial cells. This study provides new evidence of the involvement of galanin in EAE pathophysiology, but further research is warranted. multiple sclerosis,experimental autoimmune encephalomyelitis,mRNA,galanin,GalR1,GalR2,GalR3,immunohistochemistry

Author

Danica Michalickova; Ivana Kramarikova; Hatice Kubra Ozturk; Tomas Kucera; Tomas Vacik; Tomas Hrncir; Nikolina Kutinova Canova; Martin Sima; Ondrej Slanar

Publisher

Biomedical Papers