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Hypercalcaemia and drug toxicity following misuse and overdose: 2 case reports In a case series involving a 53-year-old woman and a 33-year-old man developed hypercalcaemia and cholecalciferol toxicity during consumption of colecalciferol for relapsing progressive multiple sclerosis or vitamin D deficit (overdose and misuse) [route and duration of treatment to reaction onset not stated].A 53-year-old woman (Case 1): The woman was initially admitted to the hospital for treatment of relapsing progressive multiple sclerosis, which was diagnosed 15 years prior to admission. She presented to the hospital with aggressive behavior, impaired cognition, fatigue and slow thinking, and limited ability to walk and pain in the legs and left shoulder with radiation and weakness in the left arm. In the previous 16 weeks, she had received around colecalciferol [vitamin D3] 30000 IU/days of total approximately 2500000IU (indicating drug overdose and drug misuse) to positively impact the course of her multiple sclerosis and to compensate for vitamin D deficit, as widely communicated in the media. Physical examination revealed normal and symmetrical reflexes, hyperactive biceps reflexes with an expan

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Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)