Can I read Choroid Plexus Carcinoma — Responses to Chemotherapy Alone in Newly Diagnosed Young Children on EtoBox?

Choroid Plexus Carcinoma — Responses to Chemotherapy Alone in Newly Diagnosed Young Children by Jeffrey Allen; Jeffrey Wisoff; Larry Helson; Jennifer Pearce; Edward Arenson is a Medicine article available to read on EtoBox.

What is Choroid Plexus Carcinoma — Responses to Chemotherapy Alone in Newly Diagnosed Young Children about?

Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required. Chemotherapy (CHT), as opposed to radiotherapy (RT), has a more desirable risk/benefit role in infants, since it is relatively sparing of late neurologic sequelae. Three young male children presented with large intraventricular CPC at 9, 18, and 27 months of age. One child had subarachnoid metastases at diagnosis and the other two had localized disease. Subtotal resections were accomplished and all three required VP shunts. Initial CHT consisted of four monthly courses of cisplatin (20 mg/m 2) and etoposide (100 mg/m2), both administered intravenously, daily, for five days. After four courses, two children had complete responses and one had stable disease. Additional CHT was given but one child developed a local recurrence and another diffuse CNS metastases. Both died with intratumoral hemorrhages at 5 and 57 months following diagnosis. The third child remains in cont

Who reads Choroid Plexus Carcinoma — Responses to Chemotherapy Alone in Newly Diagnosed Young Children?

Author

Jeffrey Allen; Jeffrey Wisoff; Larry Helson; Jennifer Pearce; Edward Arenson

Publisher

Springer US; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0167-594X)

Published

1992

Language

EN

Field

Medicine (Health Sciences)