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Non‐synonymous polymorphisms in the HRC and ADRB1 genes may be associated with all‐cause death in patients with non‐ischemic heart failure by Tanise Machado Telles; Bruna Miers May; Mauricio Pimentel; Bruna Letícia Da Silva Pereira; Michael Andrades; Luis Eduardo Rohde; Kátia Gonçalves Dos Santos is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Non‐synonymous polymorphisms in the HRC and ADRB1 genes may be associated with all‐cause death in patients with non‐ischemic heart failure about?
Sudden cardiac death (SCD) is an unpredictable and common mode of death in patients with heart failure (HF). Alterations in calcium handling may lead to malignant arrhythmias, resulting in SCD, and variants in calcium signaling-related genes have a significant association with SCD. Therefore, the aim of the present retrospective cohort study was to investigate the association of Ser96Ala [histidine-rich calcium-binding protein (__HRC__)], Ser49Gly [β1-adrenergic receptor (__ADRB1__)], Arg389Gly (__ADRB1__) and Gly1886Ser [ryanodine receptor 2 (__RYR2__)] polymorphisms with serious arrhythmic events and overall mortality in patients with HF with reduced left ventricular ejection fraction of non-ischemic etiology. In total, 136 patients with HF underwent physical examination, routine laboratory tests, non-invasive assessment of cardiac function and an invasive electrophysiological study. The primary outcome was the occurrence of serious arrhythmic events, set as either SCD or appropriate implantable cardioverter-defibrillator (ICD) therapy, and the secondary outcome was all-cause death. During a median follow-up of 37 months, arrhythmic events occurred in 26 patients (19%) and 41 pat
Who reads Non‐synonymous polymorphisms in the HRC and ADRB1 genes may be associated with all‐cause death in patients with non‐ischemic heart failure?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tanise Machado Telles; Bruna Miers May; Mauricio Pimentel; Bruna Letícia Da Silva Pereira; Michael Andrades; Luis Eduardo Rohde; Kátia Gonçalves Dos Santos
- Publisher
- D.A. Spandidos
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)