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Two New Balancer Chromosomes on Mouse Chromosome 4 to Facilitate Functional Annotation of Human Chromosome 1P by Ichiko Nishijima; Alea Mills; Yi Qi; Michael Mills; Allan Bradley is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Summary: To facilitate genetic screens to identify and maintain recessive mutations that map to the short arm of human chromosome 1, we have utilized chromosome engineering to generate two mouse strains that carry large inversions on the distal region of mouse chromosome 4. The inversion intervals are 16 and 22 cM in size together they cover approximately half of chromosome 4. Since recombination between the wild‐type and inversion chromosomes does not occur within these inversion intervals, mutant alleles of genes mapping to this region can be identified and maintained. Therefore, these inversion chromosomes work as balancer chromosomes. These inversions have the additional advantage that they are tagged with genes encoding the visible coat color markers tyrosinase and agouti, and therefore the dosage of the inversion chromosome (+/+, __Inv__/+, __Inv__/__Inv__) can be visually recognized. These inversion strains will be extremely useful for mutagenesis screens that focus on functional annotation of human chromosome __1p__. genesis 36:142–148, 2003. © 2003 Wiley‐Liss, Inc.

Who reads Two New Balancer Chromosomes on Mouse Chromosome 4 to Facilitate Functional Annotation of Human Chromosome 1P?

Author

Ichiko Nishijima; Alea Mills; Yi Qi; Michael Mills; Allan Bradley

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1526-954X)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)