Can I read Salvage of locally recurrent breast cancer with repeat breast conservation using 45 Gy hyperfractionated partial breast re-irradiation on EtoBox?

Salvage of locally recurrent breast cancer with repeat breast conservation using 45 Gy hyperfractionated partial breast re-irradiation by Ishita Chen; Astrid M. Botty Van den Bruele; Erin F. Gillespie; Boris A. Mueller; Amy J. Xu; John Cuaron; Atif J. Khan; Beryl McCormick; Oren Cahlon; Simon N. Powell; Hiram Cody; Lior Z. Braunstein is a Medicine article available to read on EtoBox.

What is Salvage of locally recurrent breast cancer with repeat breast conservation using 45 Gy hyperfractionated partial breast re-irradiation about?

## Purpose: Mastectomy has long been the preferred approach for local salvage of recurrent breast cancer following breast-conservation therapy (bct). growing interest in avoiding mastectomy prompted rtog 1014, a landmark phase two study demonstrating the feasibility of repeat bct using a novel radiotherapy (rt) regimen (i.e., 45 gy administered in 30 fractions of 1.5 gy twice-daily to the partial breast, "repbi"). we adopted this regimen as our institutional standard and report our observations regarding the safety and efficacy of repbi as salvage therapy. ## Methods: All patients at our institution who underwent repeat bct and subsequently received repbi from 2011 to 2019 were identified. clinicopathologic features and treatment characteristics for both primary breast cancers and recurrences were collected, as were rates of subsequent recurrence and treatment-associated toxicities. ## Results: The cohort included 34 patients with a median age of 65.8 (46.2-78.2) at the time of repbi. at a median follow-up of 23.5 months, there were two subsequent locoregional recurrences (2-year local control rate 97%). there was no grade ≥ 3 toxicity. the most common acute toxicity ( 3 months) i

Who reads Salvage of locally recurrent breast cancer with repeat breast conservation using 45 Gy hyperfractionated partial breast re-irradiation?

Author

Ishita Chen; Astrid M. Botty Van den Bruele; Erin F. Gillespie; Boris A. Mueller; Amy J. Xu; John Cuaron; Atif J. Khan; Beryl McCormick; Oren Cahlon; Simon N. Powell; Hiram Cody; Lior Z. Braunstein

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)