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The review discusses advancements in genome-edited animal models for severe combined immunodeficiency disease (SCID), highlighting the importance of these models in understanding disease mechanisms and developing therapeutic strategies. It details various gene-editing technologies, such as ZFNs, TALENs, and CRISPR/Cas9, which have enhanced the generation of SCID models across different species, including mice, rats, pigs, and monkeys. The review emphasizes the potential applications of these models in trans

Author

nayeli.18rivera

Language

EN