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Can I read Pervaporation-assisted crystallization of active pharmaceutical ingredients (APIs) on EtoBox?
Pervaporation-assisted crystallization of active pharmaceutical ingredients (APIs) by Claire Schmitz; Mohammed Noorul Hussain; Tom Meers; Zongli Xie; Liping Zhu; Tom Van Gerven; Xing Yang is a Engineering article available to read on EtoBox.
What is Pervaporation-assisted crystallization of active pharmaceutical ingredients (APIs) about?
Crystallization of active pharmaceutical ingredients is essential in pharmaceutical production. Pervaporation, a thermally-driven membrane process, has not been explored in API crystallization. Here we demonstrated PVassisted crystallization (PVaC) for simultaneous recovery of API ortho-aminobenzoic acid (o-ABA) and pure solvent. The PERVAP 4060 made of organophilic polymer was found suitable given the reasonable flux of ethanol of 3.69 kg/m 2 /h at 45 C with saturated solution and 99.9% o-ABA rejection. A parametric study showed that the membrane permeance increased with feed flow rate and temperature, but decreased with supersaturation. In the sequential PVaC, the stable form I of o-ABA was obtained with 25 C PV; while with 45 C PV, only metastable form II crystallized. In the simultaneous PVaC, at 0 time lag pure form II was produced; by increasing time lag, form I increased significantly. The results indicated potential routes to control polymorph formation via PVaC, providing a promising alternative for API production.
Who reads Pervaporation-assisted crystallization of active pharmaceutical ingredients (APIs)?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Claire Schmitz; Mohammed Noorul Hussain; Tom Meers; Zongli Xie; Liping Zhu; Tom Van Gerven; Xing Yang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)