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Nonoperative Management Following Complete Response in Rectal Cancer After Short-course Radiation Therapy and Consolidation Chemotherapy: Clinical Outcomes and Quality of Life Measures by Abhinav V. Reddy; Bashar Safar; Angela Y. Jia; Nilofer S. Azad; Eric S. Christenson; Chady Atallah; Jonathan E. Efron; Susan L. Gearhart; Atif Zaheer; Amol K. Narang; Jeffrey Meyer is a Medicine article available to read on EtoBox.

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## Purpose: The purpose of his study was to report on a cohort of patients managed with nonoperative management (NOM) with a watch-and-wait strategy after achieving complete response (CR) to sequential short-course radiation therapy (SCRT) and consolidation chemotherapy. ## Methods: This was a retrospective study of patients treated SCRT and chemotherapy who achieved a CR and were managed with NOM. Bowel function was assessed with European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30, EORTC Quality of Life Questionnaire-Colorectal Cancer 29, and the low anterior resection syndrome (LARS) questionnaires. Endpoints included overall survival (OS), freedom from local failure (FFLF), freedom from distant metastasis, and disease-free survival (DFS). ## Results: Twenty-six patients met inclusion criteria. Seven (26.9%) patients developed local failure at a median of 6.8 months following CR, of which 5 were successfully salvaged. Median FFLF was not reached, with 6-month, 1-, and 2-year FFLF rates of 100.0%, 82.3%, and 71.3%. Median OS was not reached, with 6-month, 1-, and 2-year OS rates of 100%. Median DFS was not reached, with 6-month,

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Author

Abhinav V. Reddy; Bashar Safar; Angela Y. Jia; Nilofer S. Azad; Eric S. Christenson; Chady Atallah; Jonathan E. Efron; Susan L. Gearhart; Atif Zaheer; Amol K. Narang; Jeffrey Meyer

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2022

Language

EN

Field

Medicine (Health Sciences)