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FAM83A Is a Prognosis Signature and Potential Oncogene of Lung Adenocarcinoma by Jing Yu; Min Hou; Tianxian Pei is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Lung adenocarcinoma (LUAD) is the most common subtype of nonsmall cell lung cancer, and 5-year survival rate is only 15% in recent years. This study aimed to explore the FAM83A expression and its potential functions in LUAD. Data of LUAD were downloaded from The Cancer Genome Atlas database. Expression level of FAM83A was compared between LUAD samples and adjacent normal samples. The association between FAM83A expression and clinic-pathological parameters was analyzed, as well as copy number variation and methylation status. Kaplan-Meier curve was used to visualize the relationship of FAM83A expression with survival outcomes. Finally, gene set enrichment analysis was used to identify potential signaling pathways in LUAD specimens. FAM83A expression was significantly correlated with four clinical factors in LUAD specimens, age, gender, smoking, and overall survival status (all p < 0.05). High expression level of FAM83A was negatively correlated with methylation level. Moreover, patients in low expression groups exhibited a better prognosis than those in high expressed groups, which was independent of gender ( p < 0.001). Histidine metabolism pathway was significantly upregulated in

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Author

Jing Yu; Min Hou; Tianxian Pei

Publisher

Mary Ann Liebert; Mary Ann Liebert Inc.; Mary Ann Liebert Inc (ISSN 1044-5498)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)