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Can I read Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach on EtoBox?
Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach by S. Sri Sabari; Kiruthika Balasubramani; Mahalaxmi Iyer; Harysh Winster Sureshbabu; Dhivya Venkatesan; Abilash Valsala Gopalakrishnan; Arul Narayanaswamy; Nachimuthu Senthil Kumar; Balachandar Vellingiri is a Neuroscience article available to read on EtoBox.
What is Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach about?
Growing evidence suggest that there is a connection between Parkinson's disease (PD) and insulin dysregulation in the brain, whilst the connection between PD and type 2 diabetes mellitus (T2DM) is still up for debate. Insulin is widely recognised to play a crucial role in neuronal survival and brain function; any changes in insulin metabolism and signalling in the central nervous system (CNS) can lead to the development of various brain disorders. There is accumulating evidence linking T2DM to PD and other neurodegenerative diseases. In fact, they have a lot in common patho-physiologically, including insulin dysregulation, oxidative stress resulting in mitochondrial dysfunction, microglial activation, and inflammation. As a result, initial research should focus on the role of insulin and its molecular mechanism in order to develop therapeutic outcomes. In this current review, we will look into the link between T2DM and PD, the function of insulin in the brain, and studies related to impact of insulin in causing T2DM and PD. Further, we have also highlighted the role of various insulin signalling pathway in both T2DM and PD. We have also suggested that T2DM-targeting pharmacological
Who reads Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- S. Sri Sabari; Kiruthika Balasubramani; Mahalaxmi Iyer; Harysh Winster Sureshbabu; Dhivya Venkatesan; Abilash Valsala Gopalakrishnan; Arul Narayanaswamy; Nachimuthu Senthil Kumar; Balachandar Vellingiri
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)