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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells by Rodríguez-Hernández, María A.; Chapresto-Garzón, Raquel; Cadenas, Miryam; Navarro-Villarán, Elena; Negrete, María; Gómez-Bravo, Miguel A.; Victor, Victor M.; Padillo, Francisco J.; Muntané, Jordi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells about?

Sorafenib and Regorafenib are the recommended first- and second-line therapies in patients with advanced hepatocellular carcinoma (HCC). Lenvatinib and Cabozantinib have shown non-inferior antitumoral activities compared with the corresponding recommended therapies. The clinical trials have established recommended doses for each treatment that lead different blood concentrations in patients for Sorafenib (10 μM), Regorafenib (1 μM), Lenvatinib (0.1 μM), and Cabozantinib (1 μM). However, very low response rates are observed in patients attributed to intrinsic resistances or upregulation of survival signaling. The aim of the study was the comparative dose–response analysis of the drugs (0–100 μM) in well-differentiated (HepG2, Hep3B, and Huh7), moderately (SNU423), and poorly (SNU449) differentiated liver cancer cells in 2D/3D cultures. Cells harbors wild-type p53 (HepG2), non-sense p53 mutation (Hep3B), inframe p53 gene deletion (SNU423), and p53 point mutation (Huh7 and SNU449). The administration of regular used in vitro dose (10 μM) in 3D and 2D cultures, as well as the dose–response analysis in 2D cultures showed Sorafenib and Regorafenib were increasingly effective in reducing

Who reads Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells?

Author

Rodríguez-Hernández, María A.; Chapresto-Garzón, Raquel; Cadenas, Miryam; Navarro-Villarán, Elena; Negrete, María; Gómez-Bravo, Miguel A.; Victor, Victor M.; Padillo, Francisco J.; Muntané, Jordi

Publisher

Nature Publishing Group; Springer Science and Business Media LLC; London: Nature Publishing Group, 2001- (ISSN 2041-4889)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)