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Synthesis and anthelmintic activity of thioamide analogues of cyclic octadepsipeptides such as PF1022A by Peter Jeschke; Achim Harder; Winfried Etzel; Wolfgang Gau; Gerhard Thielking; Gerhard Bonse; Katsuharu Iinuma is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Synthesis and anthelmintic activity of thioamide analogues of cyclic octadepsipeptides such as PF1022A about?

## Abstract The __tetra__‐ and __mono__‐thionated cyclic octadepsipeptides represent novel cyclic octadepsipeptide derivatives with broad‐spectrum activity against parasitic nematodes in mice and sheep. Some of these show better activity than the potent natural anthelmintic cyclic octadepsipeptide PF1022A against __Hymenolepis nana, Heterakis spumosa__ and __Trichinella spiralis__ larvae in mice. In particular, they show improved efficacy against __Haemonchus contortus__ and __Trichostrongylus colubriformis__ in sheep compared with PF1022A. Here we report on two different and simple synthetic pathways for this new class of thionated cyclic octadepsipeptides. © 2001 Society of Chemical Industry

Who reads Synthesis and anthelmintic activity of thioamide analogues of cyclic octadepsipeptides such as PF1022A?

Author

Peter Jeschke; Achim Harder; Winfried Etzel; Wolfgang Gau; Gerhard Thielking; Gerhard Bonse; Katsuharu Iinuma

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1526-498X)

Published

2001

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)