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Pulmonary Toxicity of Wollastonite in Vivo and in Vitro by E. Tátrai; Z. Kováčiková; M. Brózik; É. Six is a Environmental Science article available to read on EtoBox.

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## Abstract Pulmonary toxicity of wollastonite has been studied in both __in vivo__ long‐term sequential and __in vitro__ methods in Sprague‐Dawley rats. Wollastonite was administered by intratracheal instillation and the lungs were examined after 1, 3 and 6 months by morphological methods. UICC crocidolite was applied as the positive control. In addition, the effects of both fibres were examined in primary cultures of pulmonary alveolar macrophages and type II pneumocytes to determine the effects of the fibres on the membranes of these cells, the activity of Cu,Zn/superoxide dismutase and the redox system and the release of proinflammatory peptides: macrophage chemoattractant protein‐1 (MCP‐1) and macrophage inhibitory protein‐1__α__ (MIP‐1__α__). By the end of six months wollastonite had induced mild pulmonary interstitial fibrosis, whereas crocidolite induced progressive interstitial fibrosis as a function of time. The membranes of macrophages and pneumocytes were disrupted at the lowest concentration of crocidolite. The activity of enzymes of the redox system and cytoplasmic superoxide dismutase significantly decreased with crocidolite. Wollastonite decreased only the activity

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Author

E. Tátrai; Z. Kováčiková; M. Brózik; É. Six

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

2004

Language

EN

Field

Environmental Science (Physical Sciences)