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Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model by T. Zellweger; S. Kiyama; K. Chi; H. Miyake; H. Adomat; K. Skov; M.E. Gleave is a Medicine article available to read on EtoBox.

What is Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model about?

The paper by Zellweger et al. builds on the continuing story of clusterin (TRPM‐2) in the development and progression of prostate cancer. This group have published a series of papers on this protein, showing that it correlates with progression to androgen‐independence and resistance to apoptosis. One of their recent papers has shown that ‘knocking out’ clusterin increases radiation sensitivity in prostate cancer cells. The current paper reports that increasing the expression of clusterin in LNCaP cells increases the cell's resistance to radiation‐induced apoptosis. Manipulating identified survival proteins has important implications in preventing androgen‐independent progression. Clusterin is such a survival protein and represents an important drug target in the near future. ## OBJECTIVE To evaluate the effect of clusterin overexpression on radiation‐induced tumour growth rates and apoptosis in human prostate LNCaP cells, as prostate cancer cells are relatively resistant to radiation‐induced apoptosis and local recurrences are common, but overexpression of the anti‐apoptotic protein clusterin can accelerate progression to androgen‐independence and to confer a chemoresistant phenoty

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Author

T. Zellweger; S. Kiyama; K. Chi; H. Miyake; H. Adomat; K. Skov; M.E. Gleave

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

2003

Language

EN

Field

Medicine (Health Sciences)