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Local anesthetics are drugs that provide a reversible loss of sensation in a localized area without affecting consciousness, categorized into esters and amides based on their chemical structure. They can be administered through various routes such as surface application, infiltration, nerve blocks, and spinal or epidural anesthesia, each with specific pharmacokinetics and mechanisms of action. Adverse effects may include systemic reactions like CNS stimulation and cardiovascular issues, as well as local com

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