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Artificial Organelles with Orthogonal‐Responsive Membranes for Protocell Systems: Probing the Intrinsic and Sequential Docking and Diffusion of Cargo into Two Coexisting Avidin–Polymersomes by Wang, Xueyi (author);Moreno, Silvia (author);Boye, Susanne (author);Wang, Peng (author);Liu, Xiaoling (author);Lederer, Albena (author);Voit, Brigitte (author);Appelhans, Dietmar (author) is a Engineering article available to read on EtoBox.
What is Artificial Organelles with Orthogonal‐Responsive Membranes for Protocell Systems: Probing the Intrinsic and Sequential Docking and Diffusion of Cargo into Two Coexisting Avidin–Polymersomes about?
## Abstract The challenge of effective integration and use of artificial organelles with orthogonal‐responsive membranes and their communication in eukaryotic protocells is to understand the intrinsic membrane characteristics. Here, a novel photo‐crosslinked and pH‐responsive polymersome (Psome B) with 2‐(__N__,__N__′‐diisopropylamino)ethyl units in the membrane and its respective Avidin‐Psome B hybrids, are reported as good candidates for artificial organelles. Biotinylated (macro)molecules are able to dock and diffuse into Avidin‐Psome B to carry out biological activity in a pH‐ and size‐dependent manner. Combined with another polymersome (Psome A) with 2‐(__N__,__N__′‐diethylamino)ethyl units in the membrane, two different pH‐responsive polymersomes for mimicking different organelles in one protocell system are reported. The different intrinsic docking and diffusion processes of cargo (macro)molecules through the membranes of coexisting Psome A and B are pH‐dependent as confirmed using pH titration–dynamic light scattering (DLS). Psome A and B show separated “open”, “closing/opening”, and “closed” states at various pH ranges with different membrane permeability. The results pave
Who reads Artificial Organelles with Orthogonal‐Responsive Membranes for Protocell Systems: Probing the Intrinsic and Sequential Docking and Diffusion of Cargo into Two Coexisting Avidin–Polymersomes?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Wang, Xueyi (author);Moreno, Silvia (author);Boye, Susanne (author);Wang, Peng (author);Liu, Xiaoling (author);Lederer, Albena (author);Voit, Brigitte (author);Appelhans, Dietmar (author)
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)