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Mediterranean Essential Oils as Precious Matrix Components and Active Ingredients of Lipid Nanoparticles by C. Carbone; C. Martins-Gomes; C. Caddeo; A.M. Silva; T. Musumeci; R. Pignatello; G. Puglisi; E.B. Souto is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Mediterranean Essential Oils as Precious Matrix Components and Active Ingredients of Lipid Nanoparticles about?
Essential oils are recognized as valuable active pharmaceutical ingredients attributed to a set of biological properties, which include antibacterial, antifungal, antiviral, antioxidant, anticancer, immune-modulatory, analgesic and anti-inflammatory activities. Their use in pharmaceutics is however compromised by their limited water solubility and low physicochemical stability (i.e. volatility, oxidation). In order to overcome these limitations, we aimed to develop nanostructured lipid carriers (NLC) as delivery systems for Mediterranean essential oils, in particular Rosmarinus officinalis L., Lavandula x intermedia "Sumian", Origanum vulgare subsp. hirtum and Thymus capitatus essential oils, selected on the basis of their antioxidant and anti-inflammatory activities. NLC composed of Softisan (as solid lipid) have been produced by phase inversion temperature (PIT) and high-pressure homogenization (HPH), using two different emulsifiers systems. Particles have been further characterized for their mean particle size, polydispersity, zeta potential, morphology and chemical interactions. Best NLC formulations were obtained with Kolliphor/Labrafil as surfactants, and using Rosmarinus, La
Who reads Mediterranean Essential Oils as Precious Matrix Components and Active Ingredients of Lipid Nanoparticles?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- C. Carbone; C. Martins-Gomes; C. Caddeo; A.M. Silva; T. Musumeci; R. Pignatello; G. Puglisi; E.B. Souto
- Published
- 2018
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)