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Comparison of the compression characteristics between new one-step dry-coated tablets (OSDRC) and dry-coated tablets (DC) by Yuichi Ozeki; Yukinao Watanabe; Susumu Inoue; Kazumi Danjo is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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One-step dry-coated tablets (OSDRC) were prepared using materials which are generally used in pharmaceutical tablets. The radial tensile strength of OSDRC was measured for various compression pressures and core porosities before the final compression to compare with that of conventional dry-coated tablets (DC). Furthermore, stress relaxation in the compression process was investigated. Radial tensile strength and stress relaxation profiles of OSDRC were the same as those of conventional DC. X-ray computerized tomography (CT) of the tablets showed that the density distribution of both tablets was also the same. Thus, we concluded that OSDRC and conventional DC have the same compression characteristics and physical properties. The OSDRC-system was executed by the use of upper and lower punches, which had a double structure, a center punch, and an outer punch surrounding the center punch. The OSDRC process consists of three compressions to make the lower-outer layer (1st-outer layer), the core, and the whole tablet including the upper-outer and side-outer layers (2nd-outer layer). At first, the powder for the 1st-outer layer fills a space, which is made by the lower-center punch and l

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Author

Yuichi Ozeki; Yukinao Watanabe; Susumu Inoue; Kazumi Danjo

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2003

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)