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Lamivudine treatment for fulminant hepatic failure due to acute exacerbation of chronic hepatitis B infection by S. W. C. Tsang; H. L. Y. Chan; N. W. Y. Leung; T. N. Chau; S. T. Lai; F. K. L. Chan; J. J. Y. Sung is a Medicine article available to read on EtoBox.

What is Lamivudine treatment for fulminant hepatic failure due to acute exacerbation of chronic hepatitis B infection about?

## Background: Exacerbation of chronic hepatitis B infection can lead to fulminant hepatic failure with a mortality of up to 90%. ## Aim: To evaluate the efficacy of lamivudine in the treatment of this subgroup of patients. ## Methods: Twenty‐four patients with exacerbation of chronic hepatitis B infection and fulminant hepatic failure were treated with lamivudine, 100 mg daily. Hepatitis A, C, D and human immunodeficiency virus co‐infections and hepatocellular carcinoma were excluded. ## Results: The median age was 53 years (range, 24–77 years) with a male predominance of 20:4. Seventeen patients were hepatitis B e antigen positive. Mean hepatitis B virus DNA was 2079 Meq/mL. Eight patients (33%) survived (group A). Thirteen patients died and three patients received liver transplantation (67%) (group B). Baseline laboratory results were comparable between the two groups, including serum albumin, bilirubin, alanine aminotransferase, prothrombin time and creatinine. Group B patients had significantly more comorbid illnesses at baseline and more complications, including sepsis and renal failure, compared with group A patients. Six out of eight survivors (75%) had full hepatitis B e a

Who reads Lamivudine treatment for fulminant hepatic failure due to acute exacerbation of chronic hepatitis B infection?

Author

S. W. C. Tsang; H. L. Y. Chan; N. W. Y. Leung; T. N. Chau; S. T. Lai; F. K. L. Chan; J. J. Y. Sung

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2001

Language

EN

Field

Medicine (Health Sciences)