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Surface modification of Mitoxantrone-loaded PLGA nanospheres with chitosan by Hongli Chen; Wenzhi Yang; Han Chen; Lingrong Liu; Fuping Gao; Xindu Yang; Qian Jiang; Qiqing Zhang; Yinsong Wang is a Materials Science article available to read on EtoBox.

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The purpose of this research was to develop polylactic-co-glycolic acid (PLGA) nanospheres surface modified with chitosan (CS). Mitoxantrone- (MTO-) loaded PLGA nanospheres were prepared by a solvent evaporation technique. The PLGA nanospheres surface was modified with CS by two strategies (adsorption and covalent binding). PLGA nanospheres of 248.4+/-21.0 nm in diameter characterized by the laser light scattering technique, scanning electron microscopy (SEM) are spherical and its drug encapsulation efficiency is 84.1+/-3.4%. Zeta potential of unmodified nanospheres was measured to be negative -21.21+/-2.13 mV. The positive zeta potential of modified nanospheres reveals the presence of CS on the surface of the modified nanospheres. Modified nanospheres were characterized for surface chemistry by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT-IR). FT-IR spectra exhibited peaks at 3420 cm(-1) and 1570 cm(-1), XPS spectra shows the N 1s (atomic orbital 1s of nitrogen) region of the surface of the nanospheres, corresponding to the primary amide of CS. In vitro drug release demonstrated that CS-modified nanospheres have many advantages such as prolonged drug r

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Author

Hongli Chen; Wenzhi Yang; Han Chen; Lingrong Liu; Fuping Gao; Xindu Yang; Qian Jiang; Qiqing Zhang; Yinsong Wang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)

Published

2009

Language

EN

Field

Materials Science (Physical Sciences)