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NM23 gene expression correlates with cell growth rate and S-phase by Maria A. Caligo; Giovanna Cipollini; Lisa Fiore; Simonetta Calvo; Fulvio Basolo; Paola Collecchi; Fortunato Ciardiello; Stefano Pepe; Mario Petrini; Generoso Bevilacqua is a Medicine article available to read on EtoBox.

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## Abstract Two human __NM23__ genes have been identified: __NM23__.HI and __NM23__.H2 coding for the A and B subunit of a nucleoside diphosphate kinase (NDPK), respectively. __NM23__.HI gene has been proposed as a suppressor of metastatic ability in tumor cells, __NM23__.H2 is identical to the c‐myc transcription factor, PuF. The __NM23__ coding sequence is strongly preserved through different species. Indirect evidence of various types has been accumulated and seems to support an implication of NM23 in cell proliferation. This report shows that the __NM23__ gene expression is strictly related to the growth state of the cells. Two different __in vitro__ systems (human peripheral blood lymphocytes and human breast epithelial cell line MCF‐ 10A) and one __in vivo__ (human primary infiltrating ductal breast carcinomas) system have been investigated. The mRNA is present in PHAstimulated peripheral blood lymphocytes, whereas it is nearly undetectable in their resting counterparts. The level of the __NM23__ gene expression parallels the fraction of cells incorporating thymidine (S‐phase) in neoplastic mammary tissues. In synchronously cycling MCF‐10A cells __NM23__.HI mRNA reaches a max

Who reads NM23 gene expression correlates with cell growth rate and S-phase?

Author

Maria A. Caligo; Giovanna Cipollini; Lisa Fiore; Simonetta Calvo; Fulvio Basolo; Paola Collecchi; Fortunato Ciardiello; Stefano Pepe; Mario Petrini; Generoso Bevilacqua

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1995

Language

EN

Field

Medicine (Health Sciences)