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Regioselective C–H Silylation of Indoles by Daiann Sosa Carrizo is a document available to read on EtoBox.
This document describes a method for the regioselective C-H silylation of indoles at the C7 position. Previous methods selectively functionalized the C2 or C3 positions of indoles. The authors developed a strategy using palladium catalysis and a phosphorus(III) directing group to achieve C7 selectivity. Density functional theory calculations supported the reaction mechanism involving coordination of the catalyst to the phosphorus directing group. Using this method, diverse C7-silylated indoles were synthesi
- Author
- Daiann Sosa Carrizo
- Language
- EN