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Gut melatonin: A potent candidate in the diversified journey of melatonin research by Farha Yasmin; Sona Sutradhar; Poulami Das; Sourav Mukherjee is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Gut melatonin: A potent candidate in the diversified journey of melatonin research about?

After being discovered from the bovine pineal gland by Aaron Lerner and co-workers in the year 1958, various distinguished researchers have reported melatonin (5-methoxy-N-acetyl-tryptamine) from several extra-pineal sources, including the gastrointestinal tract (GIT). In the year 1974, Raikhlin and Kvetnoy first detected this molecule in the gastrointestinal tissue. Later, within the last 45 years, many renowned investigators found that the GIT is a rich source of melatonin, in addition to the pineal gland. In the carp gut, the estimation of Arylalkylamine-N-acetyltransferase (AANAT) mRNA/protein levels, which is the rate-determining enzyme for melatonin biosynthesis in the pineal gland, confirmed the endogenous synthesis of melatonin. The remarkable feature of the pineal gland melatonin is its rhythmic synthesis with a peak at dark-phase and lowest at light-phase in synchronization with seasonal environmental light-dark (LD) cycle. Recent studies on carp demonstrated that the melatonin concentrations and the AANAT protein intensities in different gut segments underwent significant daily fluctuations. However, compared to the melatonin rhythm in the pineal gland, the melatonin pro

Who reads Gut melatonin: A potent candidate in the diversified journey of melatonin research?

Author

Farha Yasmin; Sona Sutradhar; Poulami Das; Sourav Mukherjee

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0016-6480)

Published

2020

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)