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Can I read Protection of Gut Microbiome from Antibiotics: Development of a Vancomycin-specific Adsorbent with High Adsorption Capacity on EtoBox?
Protection of Gut Microbiome from Antibiotics: Development of a Vancomycin-specific Adsorbent with High Adsorption Capacity by Kazuki YUZURIHA; Kyosuke YAKABE; Haruka NAGAI; Shunyi LI; Takeshi ZENDO; Khadijah ZAI; Akihiro KISHIMURA; Koji HASE; Yun-Gi KIM; Takeshi MORI; Yoshiki KATAYAMA is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Protection of Gut Microbiome from Antibiotics: Development of a Vancomycin-specific Adsorbent with High Adsorption Capacity about?
The fraction of administered antibiotics that reach the cecum and colon causes dysbiosis of the gut microbiome, resulting in various diseases. Protection of the gut microbiome from antibiotics using antibiotic adsorbents in the cecum and colon is a promising method to overcome this issue. Previously, activated charcoal (AC) has been reported to protect the gut microbiome of host animals. AC is an adsorbent that is widely used to capture toxic compounds and overdosed drugs in the gastrointestinal tract. The specificity of adsorbents for antibiotics is critical to avoid the risk of unexpected side effects caused by nonspecific adsorption of biological compounds in the intestinal fluid, such as bile acids and essential micronutrients. Here, we have developed specific adsorbents for vancomycin (VCM), which is known to cause gut dysbiosis. The adsorbents were composed of polyethyleneglycol-based microparticles (MPs) in which a specific ligand for VCM, D-Ala-D-Ala-OH, was attached via dendrons of D-lysine to raise the content of the ligand in the MPs. The MPs successfully protected __Staphylococcus lentus__ from VCM __in vitro__ because of the adsorption of VCM in the culture media. Pre-
Who reads Protection of Gut Microbiome from Antibiotics: Development of a Vancomycin-specific Adsorbent with High Adsorption Capacity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kazuki YUZURIHA; Kyosuke YAKABE; Haruka NAGAI; Shunyi LI; Takeshi ZENDO; Khadijah ZAI; Akihiro KISHIMURA; Koji HASE; Yun-Gi KIM; Takeshi MORI; Yoshiki KATAYAMA
- Publisher
- BMFH Press
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)