Opening book details…
Can I read Association of Germline Genetic Variants with Breast Cancer-specific Survival in Patient Subgroups Defined by Clinicopathological Variables Related to Tumor Biology and Type of Systemic Treatment on EtoBox?
Association of Germline Genetic Variants with Breast Cancer-specific Survival in Patient Subgroups Defined by Clinicopathological Variables Related to Tumor Biology and Type of Systemic Treatment by Anna Morra; Maria Escala-Garcia; Jonathan Beesley; Renske Keeman; Sander Canisius; Thomas U. Ahearn; Irene L. Andrulis; Hoda Anton-Culver; Volker Arndt; Paul L. Auer; Annelie Augustinsson; Laura E. Beane Freeman; Heiko Becher; Matthias W. Beckmann; Sabine Behrens; Stig E. Bojesen; Manjeet K. Bolla; Hermann Brenner; Thomas Brüning; Saundra S. Buys; Bette Caan; Daniele Campa; Federico Canzian; Jose E. Castelao; Jenny Chang-Claude; Stephen J. Chanock; Ting-Yuan David Cheng; Christine L. Clarke; Anne-Lise Børresen-Dale; Kristine K. Sahlberg; Lars Ottestad; Rolf Kåresen; Ellen Schlichting; Marit Muri Holmen; Toril Sauer; Vilde Haakensen; Olav Engebråten; Bjørn Naume; Alexander Fosså; Cecile E. Kiserud; Kristin V. Reinertsen; Åslaug Helland; Margit Riis; Jürgen Geisler; Grethe I. Grenaker Alnæs; Sarah V. Colonna; Fergus J. Couch; Angela Cox; Simon S. Cross; Kamila Czene; Mary B. Daly; Joe Dennis; Thilo Dörk; Laure Dossus; Alison M. Dunning; Miriam Dwek; Diana M. Eccles; Arif B. Ekici; A. Heather Eliassen; Mikael Eriksson; D. Gareth Evans; Peter A. Fasching; Henrik Flyger; Lin Fritschi; Manuela Gago-Dominguez; José A. García-Sáenz; Graham G. Giles; Mervi Grip; Pascal Guénel; Melanie Gündert; Eric Hahnen; Christopher A. Haiman; Niclas Håkansson; Per Hall; Ute Hamann; Steven N. Hart; Jaana M. Hartikainen; Arndt Hartmann; Wei He; Maartje J. Hooning; Reiner Hoppe; John L. Hopper; Anthony Howell; David J. Hunter; Christine Clarke; Deborah Marsh; Rodney Scott; Robert Baxter; Desmond Yip; Jane Carpenter; Alison Davis; Nirmala Pathmanathan; Peter Simpson; J. Dinny Graham; Mythily Sachchithananthan; Agnes Jager; Anna Jakubowska; Wolfgang Janni; Esther M. John; Audrey Y. Jung; Rudolf Kaaks; Machteld Keupers; Cari M. Kitahara; Stella Koutros; Peter Kraft; Vessela N. Kristensen; Allison W. Kurian; James V. Lacey; Diether Lambrechts; Loic Le Marchand; Annika Lindblom; Martha Linet; Robert N. Luben; Jan Lubiński; Michael Lush; Arto Mannermaa; Mehdi Manoochehri; Sara Margolin; John W. M. Martens; Maria Elena Martinez; Dimitrios Mavroudis; Kyriaki Michailidou; Roger L. Milne; Anna Marie Mulligan; Taru A. Muranen; Heli Nevanlinna; William G. Newman; Sune F. Nielsen; Børge G. Nordestgaard; Andrew F. Olshan; Håkan Olsson; Nick Orr; Tjoung-Won Park-Simon; Alpa V. Patel; Bernard Peissel; Paolo Peterlongo; Dijana Plaseska-Karanfilska; Karolina Prajzendanc; Ross Prentice; Nadege Presneau; Brigitte Rack; Gad Rennert; Hedy S. Rennert; Valerie Rhenius; Atocha Romero; Rebecca Roylance; Matthias Ruebner; Emmanouil Saloustros; Elinor J. Sawyer; Rita K. Schmutzler; Andreas Schneeweiss; Christopher Scott; Mitul Shah; Snezhana Smichkoska; Melissa C. Southey; Jennifer Stone; Harald Surowy; Anthony J. Swerdlow; Rulla M. Tamimi; William J. Tapper; Lauren R. Teras; Mary Beth Terry; Rob A. E. M. Tollenaar; Ian Tomlinson; Melissa A. Troester; Thérèse Truong; Celine M. Vachon; Qin Wang; Amber N. Hurson; Robert Winqvist; Alicja Wolk; Argyrios Ziogas; Hiltrud Brauch; Montserrat García-Closas; Paul D. P. Pharoah; Douglas F. Easton; Georgia Chenevix-Trench; Marjanka K. Schmidt; NBCS Collaborators; ABCTB Investigators; kConFab Investigators is a nonfiction available to read on EtoBox.
What is Association of Germline Genetic Variants with Breast Cancer-specific Survival in Patient Subgroups Defined by Clinicopathological Variables Related to Tumor Biology and Type of Systemic Treatment about?
## Abstract ## Background Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients. ## Methods We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of European ancestry from the Breast Cancer Association Consortium, including 7531 breast cancer-specific deaths over a median follow-up of 8.1 years. Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. We assessed the probability of these associations being true positives via the Bayesian false discovery probability (BFDP < 0.15). ## Results Evidence of associations with breast cancer-specific survival was observed in three patient subgroups, with variant rs5934618 in patients with grade 3 tumors (15-year-hazard ratio (HR) [95% confidence interval (CI)] 1.32 [1.20, 1.45], P = 1.4E−08, BFDP = 0.01, per
Who reads Association of Germline Genetic Variants with Breast Cancer-specific Survival in Patient Subgroups Defined by Clinicopathological Variables Related to Tumor Biology and Type of Systemic Treatment?
It is typically read by self-directed learners exploring a subject in depth.
Common subject areas: history, science, philosophy, social sciences.
- Author
- Anna Morra; Maria Escala-Garcia; Jonathan Beesley; Renske Keeman; Sander Canisius; Thomas U. Ahearn; Irene L. Andrulis; Hoda Anton-Culver; Volker Arndt; Paul L. Auer; Annelie Augustinsson; Laura E. Beane Freeman; Heiko Becher; Matthias W. Beckmann; Sabine Behrens; Stig E. Bojesen; Manjeet K. Bolla; Hermann Brenner; Thomas Brüning; Saundra S. Buys; Bette Caan; Daniele Campa; Federico Canzian; Jose E. Castelao; Jenny Chang-Claude; Stephen J. Chanock; Ting-Yuan David Cheng; Christine L. Clarke; Anne-Lise Børresen-Dale; Kristine K. Sahlberg; Lars Ottestad; Rolf Kåresen; Ellen Schlichting; Marit Muri Holmen; Toril Sauer; Vilde Haakensen; Olav Engebråten; Bjørn Naume; Alexander Fosså; Cecile E. Kiserud; Kristin V. Reinertsen; Åslaug Helland; Margit Riis; Jürgen Geisler; Grethe I. Grenaker Alnæs; Sarah V. Colonna; Fergus J. Couch; Angela Cox; Simon S. Cross; Kamila Czene; Mary B. Daly; Joe Dennis; Thilo Dörk; Laure Dossus; Alison M. Dunning; Miriam Dwek; Diana M. Eccles; Arif B. Ekici; A. Heather Eliassen; Mikael Eriksson; D. Gareth Evans; Peter A. Fasching; Henrik Flyger; Lin Fritschi; Manuela Gago-Dominguez; José A. García-Sáenz; Graham G. Giles; Mervi Grip; Pascal Guénel; Melanie Gündert; Eric Hahnen; Christopher A. Haiman; Niclas Håkansson; Per Hall; Ute Hamann; Steven N. Hart; Jaana M. Hartikainen; Arndt Hartmann; Wei He; Maartje J. Hooning; Reiner Hoppe; John L. Hopper; Anthony Howell; David J. Hunter; Christine Clarke; Deborah Marsh; Rodney Scott; Robert Baxter; Desmond Yip; Jane Carpenter; Alison Davis; Nirmala Pathmanathan; Peter Simpson; J. Dinny Graham; Mythily Sachchithananthan; Agnes Jager; Anna Jakubowska; Wolfgang Janni; Esther M. John; Audrey Y. Jung; Rudolf Kaaks; Machteld Keupers; Cari M. Kitahara; Stella Koutros; Peter Kraft; Vessela N. Kristensen; Allison W. Kurian; James V. Lacey; Diether Lambrechts; Loic Le Marchand; Annika Lindblom; Martha Linet; Robert N. Luben; Jan Lubiński; Michael Lush; Arto Mannermaa; Mehdi Manoochehri; Sara Margolin; John W. M. Martens; Maria Elena Martinez; Dimitrios Mavroudis; Kyriaki Michailidou; Roger L. Milne; Anna Marie Mulligan; Taru A. Muranen; Heli Nevanlinna; William G. Newman; Sune F. Nielsen; Børge G. Nordestgaard; Andrew F. Olshan; Håkan Olsson; Nick Orr; Tjoung-Won Park-Simon; Alpa V. Patel; Bernard Peissel; Paolo Peterlongo; Dijana Plaseska-Karanfilska; Karolina Prajzendanc; Ross Prentice; Nadege Presneau; Brigitte Rack; Gad Rennert; Hedy S. Rennert; Valerie Rhenius; Atocha Romero; Rebecca Roylance; Matthias Ruebner; Emmanouil Saloustros; Elinor J. Sawyer; Rita K. Schmutzler; Andreas Schneeweiss; Christopher Scott; Mitul Shah; Snezhana Smichkoska; Melissa C. Southey; Jennifer Stone; Harald Surowy; Anthony J. Swerdlow; Rulla M. Tamimi; William J. Tapper; Lauren R. Teras; Mary Beth Terry; Rob A. E. M. Tollenaar; Ian Tomlinson; Melissa A. Troester; Thérèse Truong; Celine M. Vachon; Qin Wang; Amber N. Hurson; Robert Winqvist; Alicja Wolk; Argyrios Ziogas; Hiltrud Brauch; Montserrat García-Closas; Paul D. P. Pharoah; Douglas F. Easton; Georgia Chenevix-Trench; Marjanka K. Schmidt; NBCS Collaborators; ABCTB Investigators; kConFab Investigators
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Category
- nonfiction
More by Anna Morra; Maria Escala-Garcia; Jonathan Beesley; Renske Keeman; Sander Canisius; Thomas U. Ahearn; Irene L. Andrulis; Hoda Anton-Culver; Volker Arndt; Paul L. Auer; Annelie Augustinsson; Laura E. Beane Freeman; Heiko Becher; Matthias W. Beckmann; Sabine Behrens; Stig E. Bojesen; Manjeet K. Bolla; Hermann Brenner; Thomas Brüning; Saundra S. Buys; Bette Caan; Daniele Campa; Federico Canzian; Jose E. Castelao; Jenny Chang-Claude; Stephen J. Chanock; Ting-Yuan David Cheng; Christine L. Clarke; Anne-Lise Børresen-Dale; Kristine K. Sahlberg; Lars Ottestad; Rolf Kåresen; Ellen Schlichting; Marit Muri Holmen; Toril Sauer; Vilde Haakensen; Olav Engebråten; Bjørn Naume; Alexander Fosså; Cecile E. Kiserud; Kristin V. Reinertsen; Åslaug Helland; Margit Riis; Jürgen Geisler; Grethe I. Grenaker Alnæs; Sarah V. Colonna; Fergus J. Couch; Angela Cox; Simon S. Cross; Kamila Czene; Mary B. Daly; Joe Dennis; Thilo Dörk; Laure Dossus; Alison M. Dunning; Miriam Dwek; Diana M. Eccles; Arif B. Ekici; A. Heather Eliassen; Mikael Eriksson; D. Gareth Evans; Peter A. Fasching; Henrik Flyger; Lin Fritschi; Manuela Gago-Dominguez; José A. García-Sáenz; Graham G. Giles; Mervi Grip; Pascal Guénel; Melanie Gündert; Eric Hahnen; Christopher A. Haiman; Niclas Håkansson; Per Hall; Ute Hamann; Steven N. Hart; Jaana M. Hartikainen; Arndt Hartmann; Wei He; Maartje J. Hooning; Reiner Hoppe; John L. Hopper; Anthony Howell; David J. Hunter; Christine Clarke; Deborah Marsh; Rodney Scott; Robert Baxter; Desmond Yip; Jane Carpenter; Alison Davis; Nirmala Pathmanathan; Peter Simpson; J. Dinny Graham; Mythily Sachchithananthan; Agnes Jager; Anna Jakubowska; Wolfgang Janni; Esther M. John; Audrey Y. Jung; Rudolf Kaaks; Machteld Keupers; Cari M. Kitahara; Stella Koutros; Peter Kraft; Vessela N. Kristensen; Allison W. Kurian; James V. Lacey; Diether Lambrechts; Loic Le Marchand; Annika Lindblom; Martha Linet; Robert N. Luben; Jan Lubiński; Michael Lush; Arto Mannermaa; Mehdi Manoochehri; Sara Margolin; John W. M. Martens; Maria Elena Martinez; Dimitrios Mavroudis; Kyriaki Michailidou; Roger L. Milne; Anna Marie Mulligan; Taru A. Muranen; Heli Nevanlinna; William G. Newman; Sune F. Nielsen; Børge G. Nordestgaard; Andrew F. Olshan; Håkan Olsson; Nick Orr; Tjoung-Won Park-Simon; Alpa V. Patel; Bernard Peissel; Paolo Peterlongo; Dijana Plaseska-Karanfilska; Karolina Prajzendanc; Ross Prentice; Nadege Presneau; Brigitte Rack; Gad Rennert; Hedy S. Rennert; Valerie Rhenius; Atocha Romero; Rebecca Roylance; Matthias Ruebner; Emmanouil Saloustros; Elinor J. Sawyer; Rita K. Schmutzler; Andreas Schneeweiss; Christopher Scott; Mitul Shah; Snezhana Smichkoska; Melissa C. Southey; Jennifer Stone; Harald Surowy; Anthony J. Swerdlow; Rulla M. Tamimi; William J. Tapper; Lauren R. Teras; Mary Beth Terry; Rob A. E. M. Tollenaar; Ian Tomlinson; Melissa A. Troester; Thérèse Truong; Celine M. Vachon; Qin Wang; Amber N. Hurson; Robert Winqvist; Alicja Wolk; Argyrios Ziogas; Hiltrud Brauch; Montserrat García-Closas; Paul D. P. Pharoah; Douglas F. Easton; Georgia Chenevix-Trench; Marjanka K. Schmidt; NBCS Collaborators; ABCTB Investigators; kConFab Investigators
Similar books
- Common Germline Polymorphisms Associated with Breast Cancer-specific Survival — Alith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana M Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan Tyrer, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Alison M Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael Eriksson, Dieter Lambrechts, Caroline Weltens, Karin Leunen, Chantal van Ongeval, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Carl Blomqvist, Kristiina Aittomäki, Rainer Fagerholm, Taru A Muranen, Janet E Olson, Emily Hallberg, Celine Vachon, Julia A Knight, Gord Glendon, Anna Marie Mulligan (2015)
- The Impact of Coding Germline Variants on Contralateral Breast Cancer Risk and Survival — Anna Morra & Nasim Mavaddat & Taru A. Muranen & Thomas U. Ahearn & Jamie Allen & Irene L. Andrulis & Päivi Auvinen & Heiko Becher & Sabine Behrens & Carl Blomqvist & Stig E. Bojesen & Manjeet K. Bolla & Hiltrud Brauch & Nicola J. Camp & Sara Carvalho &... (2023)
- Practical Guide to Hereditary Breast and Ovarian Cancer : Annual Meeting of the Japanese Organization of Hereditary Breast and Ovarian Cancer 2021 — Daisuke Aoki , Seigo Nakamura , Yoshio Miki (2023)
- Germline Variants in Tumor Suppressor FBXW7 Lead to Impaired Ubiquitination and a Neurodevelopmental Syndrome — Sarah E.M. Stephenson & Gregory Costain & Laura E.R. Blok & Michael A. Silk & Thanh Binh Nguyen & Xiaomin Dong & Dana E. Alhuzaimi & James J. Dowling & Susan Walker & Kimberly Amburgey & Robin Z. Hayeems & Lance H. Rodan & Marc A. Schwartz & Jonathan... (2022)
- Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer
- An Exploratory SWATH Plasma Proteomics Analysis of Phyllodes Tumor- a Type of Female Breast Tumor — Akhter, M.D. Quasid; Dwivedi, Munish; Chitkara, Shivani; Kaur, Navneet; Bag, Swarnendu (2025)