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P048 Increased apoptosis of circulating T cells in myelodysplastic syndromes by C. Satoh; Y. Shioi; H. Tamura; N. Yokose; K. Dan; K. Ogata is a Medicine article available to read on EtoBox.

What is P048 Increased apoptosis of circulating T cells in myelodysplastic syndromes about?

Severe acquired aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are rare diseases in childhood. SAA is a bone marrow failure syndrome charecterized by immune mediated destruction of hematopoietic progenitors. MDS is a malignant clonal stem cell disorder, in which the hypoplastic variant is, in case of absence of a cytogenetic clone, difficult to separate from SAA. Recently, studies provided a "molecular signature" of autoimmunity in adult SAA, by showing oligoclonality of TCR Vbeta CDR3 region, which is refered to as TCR Vbeta skewing. We investigated the value of TCR Vbeta repertoire analysis in pediatric MDS-RC and (v)SAA patients. Methods: Peripheral blood and/or bone marrow mononuclear samples of patients with (v)SAA (n = 38), MDS-RC (n = 28) and 18 controls were analysed with Vbeta heteroduplex analysis of extracted RNA. Results: Skewing was found in 21/38 (55%) of the SAA patients and in 17/28 (61%) of the RC patients. Seventeen patients with clinical SAA showed no oligoclonality. A significant difference in TCR skewing was found between the (v)SAA + MDS-RC patients as compared to the controls (c 2 analysis, p = 0.001), but not between MDS-RC and (v)SAA (c 2 analysis

Who reads P048 Increased apoptosis of circulating T cells in myelodysplastic syndromes?

Author

C. Satoh; Y. Shioi; H. Tamura; N. Yokose; K. Dan; K. Ogata

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)

Published

2007

Language

EN

Field

Medicine (Health Sciences)