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Inadequacy of Initiating Rosuvastatin Then Metformin on Biochemical Profile of Polycystic Ovarian Syndrome Patients by G. Ghazeeri; H. A. Abbas; B. Skaff; S. Harajly; J. Awwad is a Medicine article available to read on EtoBox.

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## Background: Polycystic ovary syndrome (pcos) afflicts at least 5% of women. both metformin and statin have been used as methods to ameliorate symptoms and improve prognosis. ## Aim: To test the efficacy of concomitant usage of metformin and statins in pcos patients. ## Materials and methods: This is a prospective, randomized, double-blinded, placebo controlled study. 37 patients received rosuvastatin (10 mg/day) for a period of 3 months, then the patients were randomly allocated to one of two groups: the first group (or intervention group) received rosuvastatin (10 mg/day) plus metformin (850 mg twice daily after meals), and the second group (referred to as control group hereafter) received rosuvastatin (10 mg/day) plus placebo for a period of 3 months. biochemical and clinical data were collected at each time point. ## Results: There were no significant differences between the intervention and control groups for baseline lipid profile (ldl, hdl, triglycerides, total cholesterol), crp, homocysteine, dheas, testosterone and insulin (p > 0.05 for all variables). there were no significant differences in lipid profile, crp, homocysteine, dheas, testosterone and insulin between the i

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Author

G. Ghazeeri; H. A. Abbas; B. Skaff; S. Harajly; J. Awwad

Publisher

Springer Science and Business Media LLC

Published

2015

Language

EN

Field

Medicine (Health Sciences)