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This study investigates the impact of protein-energy malnutrition (PEM) on adaptive immunity during visceral leishmaniasis (VL), revealing that malnutrition enhances IL-10 production, which disrupts protective immune responses and increases parasite burden. Mice on a polynutrient-deficient diet exhibited reduced T cell responses and increased IL-10 levels, leading to higher susceptibility to VL. Treatment with an IL-10 receptor blocker restored anti-parasitic immunity and reduced parasite numbers, highlight

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