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Can I read IDPpi: Protein-Protein Interaction Analyses of Human Intrinsically Disordered Proteins on EtoBox?
IDPpi: Protein-Protein Interaction Analyses of Human Intrinsically Disordered Proteins by Perovic, Vladimir; Sumonja, Neven; Marsh, Lindsey A.; Radovanovic, Sandro; Vukicevic, Milan; Roberts, Stefan G. E.; Veljkovic, Nevena is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is IDPpi: Protein-Protein Interaction Analyses of Human Intrinsically Disordered Proteins about?
Intrinsically disordered proteins (IDPs) are characterized by the lack of a fixed tertiary structure and are involved in the regulation of key biological processes via binding to multiple protein partners. IDPs are malleable, adapting to structurally different partners, and this flexibility stems from features encoded in the primary structure. The assumption that universal sequence information will facilitate coverage of the sparse zones of the human interactome motivated us to explore the possibility of predicting protein-protein interactions (PPIs) that involve IDPs based on sequence characteristics. We developed a method that relies on features of the interacting and non-interacting protein pairs and utilizes machine learning to classify and predict IDP PPIs. Consideration of both sequence determinants specific for conformational organizations and the multiplicity of IDP interactions in the training phase ensured a reliable approach that is superior to current state-of-the-art methods. By applying a strict evaluation procedure, we confirm that our method predicts interactions of the IDP of interest even on the proteome-scale. This service is provided as a web tool to expedite th
Who reads IDPpi: Protein-Protein Interaction Analyses of Human Intrinsically Disordered Proteins?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Perovic, Vladimir; Sumonja, Neven; Marsh, Lindsey A.; Radovanovic, Sandro; Vukicevic, Milan; Roberts, Stefan G. E.; Veljkovic, Nevena
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)