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Can I read Outcome and Lineage Involvement in T(12;21) Childhood Acute Lymphoblastic Leukaemia on EtoBox?
Outcome and Lineage Involvement in T(12;21) Childhood Acute Lymphoblastic Leukaemia by Carlo Lanza; Gisella Volpe; Giuseppe Basso; Enrico Gottardi; Elena Barisone; Monica Spinelli; Emanuela Ricotti; Vania Cilli; Fatima Perfetto; Enrico Madon; Giuseppe Saglio is a Medicine article available to read on EtoBox.
What is Outcome and Lineage Involvement in T(12;21) Childhood Acute Lymphoblastic Leukaemia about?
The t(12;21)(p13;q22) translocation has been described recently as the most recurrent genetic lesion in paediatric acute lymphoblastic leukaemias (ALLs). It has also been associated with B‐precursor lineage involvement and good outcome. We tested 51 diagnostic paediatric ALLs and found 11 cases with molecular evidence of the t(12;21). Interestingly, amongst t(12;21) positive patients, we report three cases with hybrid phenotype, and two cases showing an aggressive and fatal disease. Our data show that the t(12;21) does not represent an independent good‐risk indicator. Long follow‐ups and additional molecular investigations are needed to assess the prognostic and pathogenetic relevance of t(12;21) in childhood ALLs.
Who reads Outcome and Lineage Involvement in T(12;21) Childhood Acute Lymphoblastic Leukaemia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Carlo Lanza; Gisella Volpe; Giuseppe Basso; Enrico Gottardi; Elena Barisone; Monica Spinelli; Emanuela Ricotti; Vania Cilli; Fatima Perfetto; Enrico Madon; Giuseppe Saglio
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)