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Can I read Aberrant RNA m^6^A modification in gastrointestinal malignancies: versatile regulators of cancer hallmarks and novel therapeutic opportunities on EtoBox?
Aberrant RNA m^6^A modification in gastrointestinal malignancies: versatile regulators of cancer hallmarks and novel therapeutic opportunities by Li-Ting Shen; Lin-Rong Che; Zongsheng He; Qian Lu; Dong-Feng Chen; Zhong-yi Qin; Bin Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Aberrant RNA m^6^A modification in gastrointestinal malignancies: versatile regulators of cancer hallmarks and novel therapeutic opportunities about?
Gastrointestinal (GI) cancer is one of the most common malignancies, and a leading cause of cancer-related death worldwide. However, molecular targeted therapies are still lacking, leading to poor treatment efficacies. As an important layer of epigenetic regulation, RNA N6-Methyladenosine (m^6^A) modification is recently linked to various biological hallmarks of cancer by orchestrating RNA metabolism, including RNA splicing, export, translation, and decay, which is partially involved in a novel biological process termed phase separation. Through these regulatory mechanisms, m^6^A dictates gene expression in a dynamic and reversible manner and may play oncogenic, tumor suppressive or context-dependent roles in GI tumorigenesis. Therefore, regulators and effectors of m^6^A, as well as their modified substrates, represent a novel class of molecular targets for cancer treatments. In this review, we comprehensively summarize recent advances in this field and highlight research findings that documented key roles of RNA m^6^A modification in governing hallmarks of GI cancers. From a historical perspective, milestone findings in m^6^A machinery are integrated with a timeline of developing
Who reads Aberrant RNA m^6^A modification in gastrointestinal malignancies: versatile regulators of cancer hallmarks and novel therapeutic opportunities?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Li-Ting Shen; Lin-Rong Che; Zongsheng He; Qian Lu; Dong-Feng Chen; Zhong-yi Qin; Bin Wang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)