About this Medicine article

Substance P in human hand veins in vivo: Tolerance, efficacy, potency, and mechanism of venodilator action* by Strobel, Werner M.; Lüscher, Thomas F.; Simper, David; Linder, Lilly; Haefeli, Walter E. is a Medicine article available to read on EtoBox.

Objectives: To study potency, efficacy, development of tolerance, and mechanism of action of substance P, an endothelium-dependent vasodilator neurokinin, in human hand veins in vivo. Methods: Thirty-three healthy subjects were studied with use of the hand vein compliance technique. In hand veins preconstricted with the cw,-agonist phenylephrme, substance P and antagonists of nitric oxide formation (L-NG-mono-methyl-arginine, L-NMMA), adenosine triphosphate (ATP)-dependent potassium channels (glyburide), angiotensin converting enzyme (enalaprilat), and cyclooxygenase (acetylsalicylic acid) were infused and the venodilator effect was measured. Results: Substance P proved to be the most potent venodilator known thus far (the dose-rate exerting 50% of mean maximum dilation [EDs,,], geometric mean: 0.105 pmol/min). Rapid development of tolerance occurred in seven of eight volunteers studied. Glyburide decreased the venodilator action of a single dose of substance I? (1.5 pmol/min) from 81% to 28% of baseline venodilation (p < 0.05), suggesting that substance P acts through release of endothelium-derived hyperpolarizing factor. The cyclooxygenaseinhibitor acetylsalicylic acid reduced su

Author

Strobel, Werner M.; Lüscher, Thomas F.; Simper, David; Linder, Lilly; Haefeli, Walter E.

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

1996

Language

EN

Field

Medicine (Health Sciences)