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Mass Spectrometry in Drug Metabolism by Alberto Frigerio and Emilio L. Ghisalberti is a book available to read on EtoBox.

What is Mass Spectrometry in Drug Metabolism about?

When a dose of drug is administered, three main phases of drug action may be distingushed. In the'pharmaceutical'phase the dosage form disintegrates, the active substance dissolves and becomes available for absorption. The second phase ('pharmaco­ kinetic'phase) includes absorption, distribution, metabolism, and excretion. That fraction of the dose which finally reaches the circulation after absorption will be available for biological action in the third, or'pharmacodynamic'phase when the drug reaches the target tissues and a drug-receptor interaction takes place. The objectives in studies of drug metabolism are: (a) to identify the pathways by which drugs are transformed in the body; (b) to ascertain quantitatively the importance of each pathway and intermediate; (c) to identify and quantify endogenous constituents influenced by the drug or its metabolites which may interfere with common metabolic processes. Since metabolites usually differ from their precursors by only a single chemical group, the resulting metabolic pathways generally consist of a series of closely related compounds. Mass spectrometry is uniquely suited for the analysis of drugs and metabolites for several reaso

Author

Alberto Frigerio and Emilio L. Ghisalberti

Publisher

Springer; Plenum Press

Published

2012

Language

EN

ISBN

9780306310188

Subjects

Science, Chemistry, Medical